Curcumin (Diferuloylmethane Derivative) With or Without Bioperine in Patients With Multiple Myeloma
Status:
Completed
Trial end date:
2009-08-01
Target enrollment:
Participant gender:
Summary
Primary Objectives:
1. To evaluate clinical tolerance and response to curcumin alone and in combination with
Bioperine in patients with multiple myeloma.
2. To compare the pharmacokinetics and pharmacodynamics of curcumin and curcumin +
Bioperine and evaluate the effect of Bioperine on the bioavailability of curcumin.
3. To evaluate the biologic effects of curcumin alone and in combination with Bioperine on
the expression of NF-kB and related genes in the Multiple Myeloma (MM) cells.