Curcumin-Simvastatin-EDTA in the Treatment of Periodontitis
Status:
Completed
Trial end date:
2018-10-03
Target enrollment:
Participant gender:
Summary
Among the root conditioning materials is the Ethylenediaminetetraacetic acid (EDTA). EDTA
exposes the collagen fibers on dentin surfaces and also enhances early cell colonization.
Statins have an anti-inflammatory effect, inhibit the bone resorption and stimulate the bone
formation. Curcumin is effective in preventing periodontal disease destruction by targeting
both bacteria and host inflammatory cells. Curcumin has anti- inflammatory, antioxidant,
anticarcinogenic, antiviral, and antimicrobial functions. This study will be carried out to
examine the effect of simvastatin-curcumin paste following EDTA root surface etching when
used in conjunction with open flap debridement treating deep periodontal pockets (suggesting
that it may have positive effect)