Curcumin and Vascular and Cognitive Function in Patients With Chronic Kidney Disease

• Status: Recruiting
• Trial end date: 2023-08-31
• Target enrollment: 0
• Participant gender: All

Summary

The proposed research is clinical study evaluating the therapeutic benefits of curcumin on vascular function in patients with chronic kidney disease (CKD). The study aims to establish that curcumin will improve endothelial function and reduce large artery stiffness by reducing oxidative stress and in conjunction with lowering markers of inflammation and oxidative stress. In addition, the study will evaluate the potential benefit of curcumin on cognitive function in patients with CKD.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Diana Jalal; University of Colorado, Denver
• Collaborators: Stanford University; University of Colorado, Boulder; University of Colorado, Denver
• Treatments: Curcumin

Criteria

Inclusion Criteria:

• CKD stage IIIB and IV

• BMI<35 kg/m2

• Able to give informed consent

Exclusion Criteria:

• Consuming a diet rich in curcumin or taking curcumin supplements in the past 12 months

• Life expectancy <1 year

• Pregnant, breastfeeding, or unwilling to use adequate birth control

• Uncontrolled hypertension

• Severe liver disease

• Severe congestive heart failure

• Hospitalization within the last 3 months

• Active infection or antibiotic therapy

• Immunosuppressive therapy within the last year