Curcuminoids and Contrast-induced Acute Kidney Injury

• Status: Completed
• Trial end date: 2019-05-31
• Target enrollment: 0
• Participant gender: All

Summary

The objective of this study was to evaluate the role of curcuminoids in the prevention of CI-AKI in CKD patients.The result of the study was prophylactic administration with curcuminoids in addition to standard treatment reduce the incidence of CI-AKI CKD patients undergoing elective CAG.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Bangkok Metropolitan Administration Medical College and Vajira Hospital

Criteria

Inclusion Criteria:

• All the patients undergoing elective CAG at Vajira hospital from October 2018 to March 2019 were included in the study

• older than 18 years old

• stable eGFR 15-60 mL/min/1.73m2 in last 3 months.

Exclusion Criteria:

• dialysis-dependent

• post-kidney transplantation

• acute heart failure or critically ill

• history of contrast or turmeric allergy

• increasing of alanine aminotransferase (ALT) or alkaline phosphatase (ALP) more than three times of normal upper limits or post-cholecystectomy

• history of AKI (as evidence by sCr change ≥ 0.3 mg/dL) within 14 days before the study
• using medication included NSAIDs, warfarin, immunosuppression, N-acetyl cysteine, ascorbic acid or contrast agents within 14 days before the study

• pregnancy or lactation o

• denied consent .