Cutaneous Prostaglandin Application: Nail Growth, Nail Brittleness, and Eye Pressure

• Status: Completed
• Trial end date: 2016-05-06
• Target enrollment: 0
• Participant gender: All

Summary

Topical prostaglandin agents are used to help reduce eye pressure in glaucoma patients. Bimatoprost (Lumigan 0.01%) is such an agent (Allergan, Inc.). Several of our patients on bimatoprost and an observational study of patients on bimatoprost in another center reported that fingernails grew longer and became less brittle using the topical eye drops to the eyes. The purpose of the double-blinded study is to determine whether the application of the eye drops directly to the proximal nail fold of one hand using the opposite hand as a control will result in longer nails, less brittle nails, and reduced eye pressures should any of the medication be absorbed into the systemic circulation.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Northwestern University
• Collaborator: Allergan
• Treatments: Bimatoprost

Criteria

Inclusion Criteria:

• English speaking

• Normotensive or glaucoma suspects on no ocular medications

• No manicure within 2 weeks of the study.

Exclusion Criteria:

• Individuals on topical or systemic essential fatty acids (EFA's) in hand lotions, creams, ointments, or medication, or on biotin.

• Digits with signs of nail injury, deformity, or infection.

• Nail biters, nail polishers, artificial nail wear or gels, and nail and trimming and filing until the study endpoint.

• Women of childbearing age who are pregnant or who are trying to become pregnant.

• Individuals with allergies or sensitivity to prostaglandin agents.