CyBorD vs. PAD in the Treatment of Newly Diagnosed Multiple Myeloma

• Status: Unknown status
• Trial end date: 2018-05-01
• Target enrollment: 0
• Participant gender: All

Summary

Bortezomib-based triple-drug combination has greatly improved the response rate of multiple myeloma patients. Bortezomib,doxorubicin,and dexamethasone (PAD) is commonly used in clinical practice.Recent studies have found that cyclophosphamide, bortezomib,and dexamethasone (CyBorD)seems better than PAD in efficacy. However, there is no randomized phase 3 trial comparing these two regimens in the treatment of newly diagnosed multiple myeloma patients.In this study, the investigators will compare the efficacy and safety of these two regimens using once-weekly subcutaneous injection of bortezomib.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Sun Yat-sen University
• Treatments: BB 1101; Bortezomib; Cyclophosphamide; Dexamethasone; Dexamethasone 21-phosphate; Dexamethasone acetate; Doxorubicin; Liposomal doxorubicin

Criteria

Inclusion Criteria:

• Newly diagnosis of multiple myeloma

• Eastern Cooperative Oncology Group (ECOG) status 0-3,

• Estimated survival time > 3 months

• Acceptable liver function (bilirubin<2.5×ULN, Alanine transaminase (ALT) or Aspartate Aminotransferase (AST)<2.5×ULN)

• No history of other malignancies

• No previous treatments including chemotherapy, radiotherapy, targeted therapy or stem cell transplantation

• No other serious diseases which conflict with the treatment in the present trial

• No concurrent treatments that conflict with the treatments in the present trial

• Voluntary participation and signed the informed consent.

Exclusion Criteria:

• The patients had the conditions below: clinically significant ventricular tachycardia (VT), atrial fibrillation (AF), heart block, myocardial infarction (MI), congestive heart failure (CHF), symptomatic coronary artery heart disease requiring medication;

• The patients participated in other clinical trials within the 30 days before enrollment or who are participating in other clinical studies

• The patients with neuropathy

• The patients with mentally ill / unable to obtain informed consent

• The patients with drug addiction, alcohol abuse which affects the long-term evaluation of test results

• The patients in pregnancy, lactation and women of childbearing age who do not want to take contraceptive measures subjects

• The patients with a history of allergy to test drug

• The patients not suitable to participate in the investigator judged by researchers.