Cycling of Sedative Infusions in Critically Ill Pediatric Patients

• Status: Terminated
• Trial end date: 2013-01-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine if the reduction of the total amount of sedative critically pediatric ill patients receive in the PICU will achieve a significant decrease in mechanical ventilation days and a decrease in the overall length of stay in the PICU and hospital.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Javier Gelvez, MD
• Treatments: Fentanyl; Hypnotics and Sedatives; Midazolam

Criteria

Inclusion Criteria:

• Less than or equal to 18 years of age

• Intubated and mechanically ventilated

• Expected to require continuous infusions of sedatives for at least 48 hours

• Parent or legal guardian available for informed consent

• Males and females of any race are eligible

Exclusion Criteria:

• Less than 72 hours after surgery

• Cyanotic heart disease with unrepaired or palliated right to left intracardiac shunt

• Critical airway (according to PICU Attending)

• Ventilator dependent (including noninvasive) on PICU admission

• Greater than 48 hours of continuous sedation infusion(s)

• Neuromuscular respiratory failure

• Managed by patient controlled analgesia (PCA) or epidural catheter

• Known allergy to any of the study medications (fentanyl or midazolam)

• Family/Medical team have decided not to provide full support (patient treatment considered futile)

• Patient requires ECMO

• Head trauma requiring intracranial pressure monitoring

• Pregnancy

• Following resuscitation from cardiorespiratory arrest whose initial pH is < 6.9

• ICU Attending judgment that patient should be excluded for safety reasons