Cyclophosphamide Versus Mycophenolate Mofetil for the Treatment of Steroid-dependent Nephrotic Syndrome in Children
Status:
Completed
Trial end date:
2015-02-01
Target enrollment:
Participant gender:
Summary
Idiopathic nephrotic syndrome is steroid-sensitive in more than 90% of cases in children.
However 60% of cases are steroid dependent and required treatment with immunosuppressive
agent. Cyclophosphamide and ciclosporin are used for long time to reduce steroid dependency,
but duration of these treatments should be restricted because of gonadotoxicity for
cyclophosphamide and nephrotoxicity for ciclosporin.
Mycophenolate mofetil appears as an alternative treatment without gonadotoxicity and
nephrotoxicity. However, contrary to cyclophosphamide, mycophenolate mofetil does not seem to
have a residual action so that treatment must be maintained during months or years.
The aim of the study is to compare efficacy of cyclophosphamide and mycophenolate mofetil in
steroid dependent nephrotic syndrome in children.