Overview

Cyclophosphamide in Treating Patients Who Are Undergoing a Donor Bone Marrow Transplant for Fanconi's Anemia

Status:
Completed
Trial end date:
1969-12-31
Target enrollment:
0
Participant gender:
All
Summary
RATIONALE: Giving low doses of chemotherapy, such as cyclophosphamide, before a donor bone marrow transplant helps stop the growth of abnormal cells. It also stops the patient's immune system from rejecting the donor's bone marrow. The donated bone marrow stem cells may replace the patient's immune system and help destroy any remaining abnormal cells. Sometimes the transplanted cells from a donor can also make an immune response against the body's normal cells. Giving cyclosporine and methotrexate before or after transplant may stop this from happening. PURPOSE: This phase I trial is studying the side effects and best dose of cyclophosphamide in treating patients who are undergoing a donor bone marrow transplant for Fanconi's anemia.
Phase:
Phase 1
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Fred Hutchinson Cancer Research Center
Collaborator:
National Cancer Institute (NCI)
Treatments:
Cyclophosphamide
Cyclosporine
Cyclosporins
Methotrexate
Criteria
DISEASE CHARACTERISTICS:

- Diagnosis of Fanconi's anemia by chromosome fragility with a diepoxybutane (DEB) or
mitomycin C test

- Hemoglobin ≤ 8.0 g/dL, absolute granulocyte count ≤ 1,000/mm^3, or platelet count
≤ 50,000/mm^3

- No refractory anemia with excess blasts, refractory anemia with excess blasts in
transformation, or acute leukemia

- HLA-identical related donor available

PATIENT CHARACTERISTICS:

- Glomerular filtration rate ≥ 30% predicted for age

- No liver disease (e.g., active hepatitis or moderate to severe portal
fibrosis/cirrhosis by biopsy)

- No symptomatic cardiac insufficiency or symptomatic arrhythmia

- No other diseases that would severely limit the probability of survival

- No HIV seropositivity

- Not pregnant or nursing

- Fertile patients must use effective contraception

PRIOR CONCURRENT THERAPY:

- Not specified