Cyclosporine A in Cardiac Arrest

• Status: Completed
• Trial end date: 2013-03-01
• Target enrollment: 0
• Participant gender: All

Summary

The investigators hypothesised that cyclosporine A administration at the onset of cardiopulmonary resuscitation, by inhibiting the mitochondrial permeability transition pore, could prevent the post cardiac arrest syndrome and improve outcomes.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Hospices Civils de Lyon
• Treatments: Cyclosporine; Cyclosporins

Criteria

Inclusion Criteria:

• Witnessed out-of-hospital cardiac arrest

• Non shockable cardiac rhythm

Exclusion Criteria:

• Evidence of trauma

• Evidence of pregnancy

• Duration of no flow more than 30 minutes

• Rapidly fatal underlying disease

• Allergy to cyclosporin A