Cytisine and E-cigarettes With Supportive Text-messaging for Smoking Cessation (Cess@Tion)

• Status: Not yet recruiting
• Trial end date: 2024-02-01
• Target enrollment: 0
• Participant gender: All

Summary

This research focuses on maximizing the benefits of proven smoking cessation interventions to support people who smoke to quit, as part of the strategy to help New Zealand become smoke-free. A large, pragmatic community-based clinical trial is planned which draws on 15 years of smoking cessation research undertaken by the study team. This research has shown that both cytisine and nicotine e-cigarettes are more effective than nicotine replacement therapy at helping people to quit smoking, and are more acceptable to users. New Zealand research has also shown that text-messages offering advice and support around quitting smoking are highly effective and acceptable. The planned trial will test whether using cytisine and nicotine e-cigarettes together will help more New Zealanders to quit smoking long-term, compared to using cytisine alone or nicotine e-cigarettes alone. Participants in all three groups will also receive smoking cessation text-messaging behavioral support.

• Phase: Phase 3
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Auckland, New Zealand
• Treatments: Nicotine

Criteria

Inclusion Criteria:

• Daily smokers who live in New Zealand

• Aged ≥18 years

• Motivated to quit smoking within the next two weeks

• Able to provide consent

• Have daily access to a mobile telephone that can text

• Have access to the internet via a computer or smart phone

• Are willing to use cytisine or an e-cigarette or both products to help quit smoking

Exclusion Criteria:

• Have another person in their household currently enrolled in the study

• Are pregnant/breastfeeding, or are women trying to become pregnant in the next three months

• Are currently using smoking cessation medication (including using e-cigarettes daily for the last month)

• Are enrolled in another cessation programme/trial

• Have a known hypersensitivity to cytisine or nicotine e-cigarettes

• Self-report moderate/severe renal impairment

• Are undergoing treatment for active/latent tuberculosis

• Have experienced a myocardial infarction, stroke, or severe angina within the previous two weeks

• Have uncontrolled high blood pressure (>150 mmHg systolic, >100 mmHg diastolic)

• Have a history of seizures / epilepsy

• Have a strong preference to use or not to use cytisine and/or e-cigarettes in their quit attempt.