D-Cycloserine as an Adjunct to Internet-CBT for OCD

• Status: Completed
• Trial end date: 2016-06-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to examine if D-Cycloserine is an effective adjunct to internet-based cognitive behaviour therapy for patients with obsessive-compulsive disorder.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Christian Rück
• Collaborators: Königska; Region Stockholm; Stockholm County Council, Sweden; The Swedish Research Council
• Treatments: Cycloserine

Criteria

Inclusion Criteria:

• Outpatients

• Male or female

• ≥ 18 years

• Currently living in Stockholm, Uppland, Örebro, Södermanland, Gästrikland, Västmanland and Östergötland county in Sweden.

• Primary diagnosis of OCD according to the DSM-IV-TR.

• Signed informed consent

• Have regular access to a computer with internet access and skills to use the web

• Have received information about the need of using contraception

Exclusion Criteria:

• Pregnancy or breast feeding

• Patients unlikely to cooperate fully in the study

• Patients not able to read or understand the basics of the ICBT self-help material

• Psychotropic medication changes within two months prior to treatment

• Completed CBT for OCD within last 12 months

• Y-BOCS [21] < 16 at Psychiatrist visit (6.2.3)pi

• OCD symptoms primarily associated with hoarding.

• Other primary axis I diagnosis according to the Mini-International Neuropsychiatric Interview (MINI) [34]

• Ongoing substance dependence

• Lifetime bipolar disorder or psychosis

• Suicidal ideation

• Axis II diagnosis that could jeopardize treatment participation

• Serious physical illness that will be an obstacle in ICBT and DCS

• Other ongoing psychological treatments that could affect OCD symptoms

• Epilepsia

• Renal impairment

• Hypersensitivity to D-Cycloserine

• Porphyria

• Chronic Alcoholism