D-Dimer Determined Anticoagulation INTENSITY in Patients With Mechanical Valve Replacement

• Status: Completed
• Trial end date: 2016-06-01
• Target enrollment: 0
• Participant gender: All

Summary

The optimal intensity of oral anticoagulation in China patients undergoing mechanical valve replacements is still controversial due to the different risk profiles of thrombophilia and bleeding in Chinese patients. Elevated D-dimer could reflect a pro-thrombogenic or prothrombotic state, and thus might be used to decide the intensity of oral anticoagulation.

This study was to evaluate whether elevated D-dimer levels could help to determine the intensity of oral anticoagulation in patients with mechanical heart valve prostheses.

• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Wuhan Asia Heart Hospital
• Treatments: Fibrin fragment D; Warfarin

Criteria

Inclusion Criteria:

1. age>18years,male or female without pregnancy;

2. Suffered the mechanical valves replacement in Wuhan Asia Heart Hospital;

3. The operation type was Mitral valve replacement or Double valves replacement(aortic and mitral valve replacement).

Exclusion Criteria: Patients with following diseases within 3 months.

1. deep venous thromboembolism

2. Pulmonary embolism

3. Aortic dissection

4. stroke

5. Cerebral hemorrhage

6. Myocardial infarction