Overview

DIAFAX I+II-Effects of Inhalative Anesthetics on Left Ventricular Diastolic Function

Status:
Terminated

Trial end date:
2010-04-01

Target enrollment:
0

Participant gender:
All

Summary

Anaesthetics may impair the diastolic function of the heart, but the importance of this finding for patients has not been sufficiently examined. Specially the effects on diastolic function in patients with diastolic dysfunction has to be determined. The aim of this study is to examine the effect of isoflurane (only part I), sevoflurane and desflurane (part I+II) on the diastolic left ventricular function by doppler echocardiography.

Phase:

Phase 4

Accepts Healthy Volunteers?

Details

Lead Sponsor:

University Hospital, Basel, Switzerland

Treatments:

Anesthetics
Desflurane
Isoflurane
Remifentanil
Sevoflurane

Criteria

Inclusion Criteria:

- part I: 18- to 50-year-old patients undergoing surgical procedures under general
anesthesia

- part II: 50-years-old patients or older with arterial hypertension under chronic
antihypertensive medication subsequently undergoing surgical procedures under general
anesthesia, EF >50%

Exclusion Criteria:

- part I: any cardiac or pulmonary disease, any medication with cardiovascular effects
or side effects, body mass index > 30 kg/m2, esophageal reflux, emergency

- part II: History of myocardial infarction or coronary revascularization, severe lung
disease, body mass index > 30 kg/m2, esophageal reflux, emergency