Overview

DISCERN: Dual Versus Single ICB in PDL-1 Negative NSCLC

Status:
RECRUITING
Trial end date:
2027-09-01
Target enrollment:
Participant gender:
Summary
The purpose of this study, known as DISCERN, is to compare two different treatments for a type of lung cancer called non-small cell lung cancer (NSCLC) that does not show a marker known as PD-L1. This study will help us understand if using two types of immune therapy together with chemotherapy is better than using one type of immune therapy with chemotherapy. We're doing this by looking at changes in the subject's cancer's DNA in the blood after starting treatment.
Phase:
PHASE2
Details
Lead Sponsor:
University of Alabama at Birmingham
Treatments:
Carboplatin
Ipilimumab
Nivolumab
Paclitaxel
pembrolizumab
Pemetrexed