Postoperative management of oral anticoagulation is a frequent preoccupation in cardiac
surgery, concerning about half of patients. Vitamin K antagonists are often recommended but
their management is not easy due to the high dose-response patient variability.
Pharmacologically more stable, direct oral anticoagulants have similar efficiency in
preventing thromboembolic complications while they decrease the risk of bleeding in certain
patient populations. The objective of study is to assess the safety and efficacy of direct
oral anticoagulants in the postoperative period of cardiac surgical procedures.
Phase:
Phase 2
Details
Lead Sponsor:
Laval University
Treatments:
Anticoagulants Apixaban Dabigatran Edoxaban Rivaroxaban Vitamin K Warfarin