DOX as a Potential Treatment for Methamphetamine Dependence
Status:
Completed
Trial end date:
2016-03-01
Target enrollment:
Participant gender:
Summary
The purpose of the study is to asses the potential interactions between methamphetamine and
doxazosin in methamphetamine-dependent volunteers who are not seeking treatment. The study
will evaluate the effects of doxazosin on the cardiovascular and subjective effects of
methamphetamine in a human laboratory study.
The primary objective is to determine the safety of treatment with doxazosin in
methamphetamine-dependent volunteers by examining hemodynamic and subjective effects of
administration of ascending doses of methamphetamine and a placebo dose during treatment with
doxazosin.
The secondary objective is to determine effects of treatment with doxazosin, as compared to
placebo, on subjective effects produced by administration of methamphetamine or placebo