Daily Isoniazid to Prevent Tuberculosis in Infants Born to Mothers With HIV
Status:
Terminated
Trial end date:
2009-05-01
Target enrollment:
Participant gender:
Summary
Tuberculosis (TB) is highly endemic in sub-Saharan Africa. The increased burden of TB in
settings with high prevalence of the Human Immunodeficiency Virus (HIV) is associated with
high rates of transmission of Mycobacterium tuberculosis (M.tb) to both adults and children.
Children infected with TB have a higher risk of developing severe disease than adults with
TB. The purpose of this study was to determine if the antibiotic isoniazid (INH) prevented TB
infection in infants born to HIV-infected mothers.
Phase:
Phase 2/Phase 3
Details
Lead Sponsor:
International Maternal Pediatric Adolescent AIDS Clinical Trials Group
Collaborators:
Comprehensive International Program of Research on AIDS National Institute of Allergy and Infectious Diseases (NIAID) Secure the Future Foundation