Dalfampridine Combined With Physical Therapy for Mobility Impairment in Multiple Sclerosis
Status:
Not yet recruiting
Trial end date:
2026-06-01
Target enrollment:
Participant gender:
Summary
The goal of this clinical trial is to evaluate if combining a medication that can help
improve walking in people with multiple sclerosis (MS) with a physical therapy program is
better for improving walking than either treatment alone. The main questions this study will
answer are:
- Does combining dalfampridine with physical therapy improve mobility more than physical
therapy without concurrent dalfampridine?
- Is the combined treatment associated with better outcomes than the medication
(dalfampridine) on its own?
- How do the individual treatments (dalfampridine, physical therapy) alone compare to each
other?
Participants with MS-related mobility deficits will:
- Receive 6 weeks of dalfampridine treatment to assess the effects of this treatment.
- After stopping the medication for 2 weeks, the investigators will re-evaluate walking,
then randomly assign individuals to a 6-week physical therapy program.
- Half of the participants will receive physical therapy while resuming dalfampridine
treatment. The other half of the participants will receive physical therapy without
resuming the medication.
Researchers will compare the combination treatment group (medication plus physical therapy)
to the physical therapy only group to see if the combined treatment improves walking-related
function. Approximately 3 months after finishing the physical therapy program, participants
will undergo a final evaluation to see if the treatment effects have been maintained.