Danish Aspirin Resistance Trial - Pilot Study

• Status: Completed
• Trial end date: 2007-03-01
• Target enrollment: 0
• Participant gender: All

Summary

Despite treatment with aspirin a large number of patients suffer a myocardial infarction. It has been speculated that these patients might be "resistant" to aspirin, and studies have indicated that this phenomenon is related to a less favourable prognosis. At present, no international consensus exists on how to measure "aspirin resistance". The purpose of this study is to compare different methods for detecting "aspirin resistance". A classic but cumbersome way of evaluating platelet function will be compared to newer, easy-handling point-of-care tests. We hypothesize that one or more point-of-care tests will prove to be superior to the classic platelet function test in detecting aspirin resistance.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Aarhus
• Collaborator: Danish Research Agency
• Treatments: Aspirin

Criteria

Inclusion Criteria:

• ischemic heart disease verified with a coronary angiogram

• treatment with 75 mg aspirin once daily

Exclusion Criteria:

• ischemic vascular event within the previous 12 months

• percutaneous coronary intervention or coronary artery by-pass grafting within the previous 12 months

• treatment with NSAID, clopidogrel, ticlopidine, dipyridamole, warfarin or any other drug affecting platelet aggregation

• platelet count < 120 x 10^9/l

• not able to give informed consent