Hypothesis: Use of hormone replacement therapy (HRT) decreases the incidence of fractures in
early postmenopausal women.
The project was initiated in 1990, and the inclusion ended in 1993. A total of 2,016 early
postmenopausal women were divided into two groups: The first group accepted randomisation to
HRT or not, and the second group was allowed to choose HRT or not.
The study was not blinded. Main measurements were fracture risk over 20 years, changes in
bone mineral density over 20 years, and side effects, mainly breast cancer.
Phase:
Phase 4
Details
Lead Sponsor:
University of Aarhus
Collaborators:
Karen Elise Jensen Foundation LEO Pharma Novartis Novo Nordisk A/S