Dapagliflozin vs Empagliflozin on Flow Mediated Dilation in Type 2 Diabetes Mellitus
Status:
Not yet recruiting
Trial end date:
2020-12-30
Target enrollment:
Participant gender:
Summary
Type 2 diabetes mellitus (T2DM) is a considered one of the main global health challenges; the
vascular endothelium plays an important role in vascular dysfunction in DM; Hyperglycemia
induced by it is recognized as the main factor for the development of vascular complications
of the disease, secondary to a reduction in nitric oxide production; "flow-mediated dilation"
is the most commonly used technique for the evaluation of endothelial function, being the
non-invasive method most widely used. It has been reported that with the use of SGLT2
inhibitors the development of cardiovascular complications in patients with T2DM is a
decrease, as well the arterial stiffness, endothelial dysfunction and increasing on the shear
stress and blood viscosity; and experimentally.
Phase:
Phase 3
Details
Lead Sponsor:
Centro Universitario de Ciencias de la Salud, Mexico