Daptomycin as Antibiotic Prophylaxis of Sternal Wound Infections

• Status: Completed
• Trial end date: 2012-03-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to show that the incidence of sternal wound infections at day 30 after cardiac surgery is 50% lower with the additional use of Daptomycin on top of a standard antibiotic prophylaxis as compared to the standard antibiotic prophylaxis alone.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Hannover Medical School
• Collaborator: Novartis
• Treatments: Anti-Bacterial Agents; Antibiotics, Antitubercular; Cefuroxime; Cefuroxime axetil; Daptomycin

Criteria

Inclusion Criteria:

• age between 18-80

• written informed consent (IC)

Exclusion Criteria:

• pregnant and lactating women

• patients operated for a transplantation

• patients with a increased myopathy risk

• patients with a creatinine clearance < 30ml/min; patients on hemodialysis

• patients after a previous sternotomy

• treatment with any antibiotics 14 days prior study start

• treatment with Daptomycin or Cefuroxime within 3 month prior study start