Daptomycin in Pediatric Patients With Bacterial Meningitis
Status:
Terminated
Trial end date:
2018-06-30
Target enrollment:
Participant gender:
Summary
5 Children > 3months and < 16 years with Gram-positive meningitis will receive a single dose
of daptomycin 24 hours after the first dose of ceftriaxone. 4-8 hours after daptomycin
administration a second lumbar puncture is performed to determine the peak concentration of
daptomycin in the cerebrospinal fluid. In parallel peak and trough level of daptomycin will
be measured in the plasma. The investigators anticipate that daptomycin penetrates into the
cerebrospinal fluid in bactericidal concentrations