Decolonization to Reduce After-Surgery Events of Surgical Site Infection
Status:
Not yet recruiting
Trial end date:
2028-12-01
Target enrollment:
Participant gender:
Summary
The DECREASE SSI Trial (Decolonization to Reduce After-Surgery Events of Surgical Site
Infection) is a two-arm multi-center individual placebo-controlled randomized (2,700
participants randomized 1:1) clinical trial to reduce post-discharge surgical site infection
following open colon or small bowel surgery by comparing chlorhexidine bathing plus nasal
mupirocin in the 30 days following discharge to soap without antiseptic properties (placebo)
and placebo nasal ointment. This trial seeks to enhance the care of the 675,000 patients
annually who undergo colon and small bowel surgery by finding simple and efficacious
interventions to reduce SSI.
Phase:
Phase 4
Details
Lead Sponsor:
University of California, Irvine
Collaborators:
University of California, Davis University of California, San Francisco University of Massachusetts, Amherst
Treatments:
Anti-Infective Agents, Local Chlorhexidine Chlorhexidine gluconate Mupirocin