Decreasing Postoperative Blood Loss by Topical vs. Intravenous Tranexamic Acid in Open Cardiac Surgery

• Status: Completed
• Trial end date: 2018-09-04
• Target enrollment: 0
• Participant gender: All

Summary

The aim is to conduct a double-blinded single-centre randomized controlled clinical trial of application of topical dose of tranexamic acid (TA) versus the usual intravenous TA in patients undergoing cardiac surgery at the Hamilton General Hospital. This pilot study will assess the feasibility to perform a large randomized international trial exploring this objective.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Population Health Research Institute
• Treatments: Tranexamic Acid

Criteria

Inclusion Criteria:

• Male or female >= 18 years old

• Undergoing cardiac surgical procedure with the use of cardiopulmonary bypass and median sternotomy

• Provide written informed consent

Exclusion Criteria:

• Poor (English) language comprehension

• Minimally invasive valve surgery

• Off-pump procedures

• Emergency operations

• Known history of increased bleeding disorder

• Thromboembolic disease

• Allergy to tranexamic acid

• Severe renal impairment (eGFR <30 mL/min/1.73m2 )