Overview

Deep Neuromuscular Block for Laparoscopic Surgery

Status:
Completed
Trial end date:
2019-04-01
Target enrollment:
0
Participant gender:
All
Summary
Trial summary: deep neuromuscular block is proposed as a technique to improve operative conditions for laparoscopy. Early clinical data would suggest that there may also be patient benefits beyond the operative period related to lower intra-abdominal pressure, and improved surgical exposure. In order to safely conduct deep neuromuscular blockade, it is essential to use Sugammadex to reverse the neuromuscular block. Conventional practice is to provide moderate neuromuscular block and reverse with neostigmine. It is not possible to safely reverse deep neuromuscular block using neostogmine, as the majority of block must have worn off for neostigmine to be effective. in order to identify whether deep neuromuscular block improves quality of recovery after surgery, the investigators will conduct a randomised trial of deep versus moderate neuromuscular block, whilst minimising variance in other anaesthetic techniques and drugs used. the outcome measured will be the post-operative quality of recovery over multiple time periods using the Postoperative Quality of Recovery Scale (PostopQRS). 350 patients will be enrolled over 4 centres.
Phase:
Phase 4
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
University of Melbourne
Collaborators:
Melbourne Health
Northpark Private Hospital
Northpark Private hospital (Healthscope)
Peter MacCallum Cancer Centre, Australia
Royal Hospital For Women
The Royal Womens Hospital Melbourne
Victorian Comprehensive Cancer Centre Peter Macallum hospital)
Treatments:
Neostigmine
Criteria
Inclusion Criteria:

1. Adult participants

2. operative gynecological or abdominal surgery

3. receiving general anesthesia

4. Operation expected to exceed1 hour duration

5. Participants must speak sufficient English to answer the survey questions

Exclusion Criteria:

1. Participants undergoing diagnostic laparoscopy only

2. Participants <18 years of age

3. Current pregnancy

4. Known allergy to rocuronium, neostigmine or sugammadex, or desflurane