Deep Neuromuscular Blockade During Robotic Radical Prostatectomy

• Status: Unknown status
• Trial end date: 2016-03-01
• Target enrollment: 0
• Participant gender: Male

Summary

Basic requirement for safe performance of the robotic intra-abdominal surgery is a calm and clear surgical field after the introduction of a capnoperitoneum. That can be enabled by a neuromuscular blockade. Provision of standard neuromuscular blockade is a compromise between optimal surgical conditions (sufficiently deep block) and capability to antagonize the block rapidly at the end of the surgery. With rocuronium, it is possible to maintain deep neuromuscular blockade safely until the very end of the surgery, and unlike with spontaneous recovery or reversal of the block with neostigmine, administration of sugammadex at the end of the surgery will enable quick and consistent reversal of the block. Project is focused on comparison of the parameters of deep and standard neuromuscular blockade - surgical conditions (primary endpoint), quality of recovery and turnover time (secondary endpoints).

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Palacky University
• Collaborators: Masaryk Hospital Usti nad Labem; Masaryk Hospital, Usti nad Labem; University Hospital Olomouc
• Treatments: Neostigmine; Rocuronium

Criteria

Inclusion Criteria:

• Age over 18 years

• Informed consent

• Elective robotic radical prostatectomy

• American Society of Anesthesiologists (ASA) status 1-3

Exclusion Criteria:

• Age under 18 years

• American Society of Anesthesiologists (ASA) status over 3

• Indication for rapid sequence induction, signs of difficult airway severe neuromuscular, liver or renal disease

• Known allergy to drugs used in the study

• Malignant hyperthermia (medical history)