Degarelix Before Radical Prostatectomy

• Status: Unknown status
• Trial end date: 2015-12-01
• Target enrollment: 0
• Participant gender: Male

Summary

The biological effects of castration on prostate cancers will be studies by administration of degarelix prior to radical prostatectomy.

The effects will be studied by analysis of gene expression and immunohistochemistry focusing on markers of proliferation and apoptosis of samples taken at the time of radical prostatectomy (7 days after administration of degarelix).

Tumours from patients treated with neo-adjuvant degarelix will be compared with tumours from patients who have not been medically castrated.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Cambridge
• Treatments: Testosterone

Criteria

Inclusion Criteria:

• Intermediate/high risk prostate cancer

• Patient eligible for and wanting surgery

Exclusion Criteria:

• Inability to consent

• Previous thromboembolism/arrhythmias

• contraindication to degarelix or surgery