Dehydroepiandrosterone (DHEA) and Letrozole in Treating Patients With Metastatic Breast Cancer
Status:
Terminated
Trial end date:
2010-12-01
Target enrollment:
Participant gender:
Summary
RATIONALE: Androgens can cause the growth of breast cancer cells. Hormone therapy using
dehydroepiandrosterone (DHEA) may fight breast cancer by blocking the use of androgen by the
tumor cells. Letrozole may stop the adrenal glands from making androgens. Giving DHEA
together with letrozole may kill more tumor cells.
PURPOSE: This phase I trial is studying the side effects and best dose of DHEA when given
together with letrozole in treating patients with metastatic breast cancer.