Delirium Reduction by Volatile Anesthesia in Cardiac Surgery

• Status: Recruiting
• Trial end date: 2022-01-29
• Target enrollment: 0
• Participant gender: All

Summary

Parallel group, prospective, randomized, controlled, single-blinded trial. The aim of our study is to test the hypothesis that volatile anesthesia would reduce the incidence of early postoperative delirium in patients undergoing cardiac surgery with CPB as compared to TIVA.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Meshalkin Research Institute of Pathology of Circulation
• Treatments: Anesthetics; Desflurane; Isoflurane; Propofol; Sevoflurane

Criteria

Inclusion Criteria:

• Males and females > 65 years

• Written informed consent

• Cardiac surgery with CPB

Exclusion Criteria:

• Emergency surgery

• Surgery on aorta

• Known allergy to components of anaesthesia

• Pregnancy

• Hemodynamically significant stenosis of carotid arteries

• Parkinson's disease

• Liver cirrhosis (Child B or C)

• Current enrollment into another RCT (in the last 30 days)

• Previous enrollment and randomization into the DELICATE trial

• Poor language comprehension

• Preoperative Medications: Anticholinergics (dimedrol, atropine, dramina), antidepressants, antiepileptics, antiparkinson drugs, chemotherapeutic agents