Delivery of Malaria Chemoprevention in the Post-discharge Management of Children With Severe Anaemia in Malawi
Status:
Unknown status
Trial end date:
2019-12-01
Target enrollment:
Participant gender:
Summary
Background and rationale: Children hospitalised with severe anaemia in Africa are at high
risk of readmission or death within 6 months after discharge. No strategy specifically
addresses this post-discharge period. In Malawi, 3 months of post-discharge malaria
chemoprevention (PMC) with monthly 3-day treatment courses of artemether-lumefantrine (AL) in
children with severe malarial anaemia prevented 31% of deaths and readmissions. The effect
was in addition to the effect of insecticide-treated bednets. There is now need to design and
evaluate effective delivery mechanism for PMC within the health system.
Phase:
Phase 3
Details
Lead Sponsor:
University of Malawi College of Medicine
Collaborators:
Imperial College London Kenya Medical Research Institute Liverpool School of Tropical Medicine London School of Hygiene and Tropical Medicine Makerere University Ministry of Health and Population, Malawi Ministry of Health, Malawi The Research Council of Norway Universiteit van Amsterdam University of Amsterdam University of Bergen University of Minnesota University of Minnesota, MN