Depot Naltrexone Mechanism of Action in Heroin Dependent Patients Using fMRI and SPECT
Status:
Completed
Trial end date:
2014-10-01
Target enrollment:
Participant gender:
Summary
The aim of this project is to study brain functions of 20 heroin addicts (compared to brain
functions of 20 healthy controls) just before and during a three month extended release
naltrexone treatment using functional MRI and dopamine transporter SPECT.
The following hypotheses are tested:
- XRNT modulates the fMRI response to drug cues in predetermined brain regions.
- The expression of striatal transporters (assessed with SPECT) will decrease after a
three-month course of extended release naltrexone
Phase:
Phase 4
Details
Lead Sponsor:
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Collaborators:
Alkermes, Inc. ZonMw: The Netherlands Organisation for Health Research and Development