Depression: The Search for Treatment-Relevant Phenotypes-Pilot Study

• Status: Completed
• Trial end date: 2004-09-01
• Target enrollment: 0
• Participant gender: All

Summary

We are doing this pilot study to learn more about four aspects of treating depression:

1. The features of a depressed person's mood and anxiety and how these features affect a person's capacity to get better and stay better.

2. If depressed people with certain features of mood and anxiety respond better to therapy, medication or a combination of therapy and medication.

3. Whether or not a person's personality traits affect how they respond to treatment.

4. The gene involved in processing antidepressant medication

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Pittsburgh
• Collaborator: Mental Health Intervention Research Center (MHIRC)
• Treatments: Citalopram

Criteria

Inclusion Criteria:

1. Men and women 2 Age 18-65 3. Currently experiencing an episode of major depression 4. Not currently receiving effective treatment 5. Females of childbearing potential: practicing an acceptable form of birth control 6. Subjects with suicidal ideation are eligible as long as outpatient treatment is deemed safe 7. Willingness and ability to give informed consent.

Exclusion Criteria:

1. History of manic or hypomanic episodes;

2. History of schizophrenia or schizoaffective disorder;

3. Current primary diagnosis of anorexia nervosa or bulimia nervosa;

4. Current psychosis;

5. Drug and/or alcohol dependence or abuse within the past three months (episodic abuse related to mood episodes will not exclude a subject);

6. Antisocial personality disorder (other Axis II disorders will not be exclusionary);

7. Organic affective syndrome;

8. Renal or liver disease;

9. Epilepsy;

10. Cardiovascular disease;

11. Uncontrolled illnesses, including untreated hypertension or unstable endocrine diseases.

12. Women who are or are plan to become pregnant during the course of this study

13. Subjects who require inpatient treatment because of suicidal risk or psychosis

14. Subjects with a well-documented history of an inability to tolerate one of the study treatments or are currently receiving treatment with an effective antidepressant therapy