Derris Scandens Benth Extract VS Naproxen in Knee OA

• Status: Completed
• Trial end date: 2009-03-01
• Target enrollment: 0
• Participant gender: All

Summary

Derris Scandens Benth (family : Leguminosae) is a woody vine growing throughout Southeast Asia, including Thailand. The stem of D.Scandens has been widely use in Thai traditional medicine, foe example of myalgia. Previous study shown that D.Scandens Benth extract has the anti-inflammatory activity. Although NSAIDs are efficaciously in the treatment of osteoarthritis,but the GI side effect is still concerned. In this study we aim to investigate the efficacy and safety of D. Scandens Benth extract compared with Naproxen for therapy of patients with knee osteoarthritis.

• Phase: Phase 3
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Mahidol University
• Collaborator: Ministry of Health, Thailand
• Treatments: Naproxen

Criteria

Inclusion Criteria:

• Age >=50 yr

• Known case of primary knee osteoarthritis

• WOMAC pain subscale (item1) >= 5

• signed informed consent

Exclusion Criteria:

• hypersensitive to NSAIDs

• history of peptic ulcer or melena

• unable to walk , i.e. patient with severe spinal stenosis, myocardial infarction

• history of intra-articular injection of knee within 3 months

• status post knee replacement