Desflurane,Brain Natriuretic Peptide and Cardiac Surgery

• Status: Completed
• Trial end date: 2014-09-30
• Target enrollment: 0
• Participant gender: All

Summary

During coronary artery bypass grafting (CABG) operations with cardiopulmonary bypass (CPB), the use of desflurane continuously or intermittently may have effects on serum brain natriuretic peptide (BNP) levels. The aim is to investigate the association between desflurane, serum BNP values, and clinical outcomes during CABG operations. In a prospective, randomized, double-blinded study, desflurane inhalational anesthesia was administered either continuously or intermittently (Group 1; n=60 versus Group 2; n=62). The preoperative and postoperative BNP levels at 24, 48 and 72 hours after surgery were collected. Outcomes were recorded.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital
• Collaborator: Trakya University Faculty of Medicine Hospital
• Treatments: Desflurane; Natriuretic Peptide, Brain

Criteria

Inclusion Criteria:

• Eighteen to seventy-five years of age,

• Body mass index values between twenty-five and thirty-one,

• Ejection fraction greater than or equal to 50%.

Exclusion Criteria:

• Repeat cardiac surgery,

• Emergent surgery,

• Preoperative coagulation disorder,

• Preoperative congestive heart failure,

• Ejection fraction less than 49%,

• Preoperative renal dysfunction (serum creatinine value of greater than 1.3 mg/dL),

• Dialysis,

• Preoperative hepatic dysfunction (serum aspartate/alanine amino transferase values of greater than 40 U/L),

• Preoperative electrolyte imbalance,

• History of pancreatitis,

• Current corticosteroid treatment.