Desflurane and Anesthesia Recovery Period in Endonasal Endoscopic Pituitary Adenoma Resection

• Status: Not yet recruiting
• Trial end date: 2022-08-31
• Target enrollment: 0
• Participant gender: All

Summary

Nasal packing is required after endoscopic pituitary adenoma resection. The patient can only breathe through the mouth. The blood and secretion in the nasal cavity may be inhaled into the trachea after the operation. GH-secreting pituitary adenoma causes pharyngeal soft tissue and tongue hypertrophy. These conditions increase the risk of respiratory obstruction and hypoxemia during anesthesia recovery. Propofol total intravenous anesthesia has a rapid effect and a low incidence of nausea and vomiting. Patients anesthetized with desflurane recover quickly is conducive to early recovery of respiratory function and orientation. This study intends to compare the effects of desflurane and propofol on the quality of anesthesia recovery period in patients undergoing endonasal endoscopic pituitary adenoma resection and to provide clinical evidence for the use of desflurane in neurosurgical anesthesia.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Beijing Tiantan Hospital
• Treatments: Desflurane; Propofol

Criteria

Inclusion Criteria:

• 18-65 years;

• Elective endoscopic transsphenoidal resection of pituitary adenomas;

• ASA status I-III;

• Informed consent signed by patients.

Exclusion Criteria:

• Complicated with cerebrovascular disease;

• Complicated with lung disease, the SpO2 is less than 95% without oxygen inhalation;

• It is expected to retain endotracheal intubation after operation;

• The disturbance of consciousness can not cooperate with the evaluation before operation;

• Complicated with hypothyroidism;

• The previous history of neck surgery, burns, radiotherapy;

• Invasive pituitary adenomas with Knosp grade 4.