Desflurane and Brain Relaxation in Craniotomy

• Status: Completed
• Trial end date: 2021-08-31
• Target enrollment: 0
• Participant gender: All

Summary

Optional brain relaxation improves the surgeon's operating conditions and is likely to minimize the degree of retraction injury ,with the potential for providing patients with a better outcome. The choice of anesthetic drugs can affect intraoperative brain relaxation. Propofol suppresses brain metabolism, reduces cerebral blood flow, and provides satisfactory brain relaxation. Desflurane is often criticized in neurosurgery due to its cerebral vasodilation and potential to increase intracranial pressure, however, it has been found to have a little clinical significance. This study intends to compare the effects of desflurane with propofol on brain relaxation in patients with supratentorial tumors under mild hyperventilation, and to provide new clinical evidence for the use of desflurane in neurosurgical anesthesia.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Beijing Tiantan Hospital
• Treatments: Anesthetics; Desflurane; Propofol

Criteria

Inclusion Criteria:

• 18-60 years

• Scheduled for elective craniotomy for supratentorial cerebral tumors

• ASA status I-III

• Glasgow score of 15

• No clinical signs of intracranial hypertension

• Preoperative brain imaging (CT or MRI) with midline shift less than 5mm

• Informed consent signed by patients

Exclusion Criteria:

• Scheduled intraoperative motor evoked potential monitoring

• Patients with cerebral vascular diseases

• Uncontrolled cardiopulmonary disease

• Schedule to retain tracheal intubation after surgery

• Unable to comprehend and cooperate with the examination

• BMI > 30 Kg/m-2

• Emergency surgery

• History of related anesthetic allergy