Desflurane and Its Effect on Postoperative Morbidity and Mortality in Patients Undergoing Thoracic Surgery
Status:
Completed
Trial end date:
2014-12-01
Target enrollment:
Participant gender:
Summary
Desflurane and its effect on postoperative morbidity and mortality in patients undergoing
thoracic surgery.
Halothane, enflurane, isoflurane, sevoflurane, and desflurane are volatile anesthetics, a
group of general anesthetics. Because of the hypnotic effects of these agents, attention has
mainly focused on the central nervous system. In the last 10 years, however, numerous studies
have reported that volatile anesthetic agents interact with membrane structures of the
myocardium and thereby attenuate cardiac mechanical dysfunction and limit ultrastructural
abnormality on reperfusion after prolonged ischemia in the myocyte. Anesthetic-induced
preconditioning has become a main topic in cardiac research worldwide
- Trial with medicinal product
Phase:
Phase 4
Details
Lead Sponsor:
University of Zurich
Collaborators:
Cantonal Hospital of St. Gallen Kantonsspital Münsterlingen University Hospital Inselspital, Berne University Hospital, Basel, Switzerland