Desmopressin in the Treatment of Mixed Nocturia With Nocturnal Polyuria and Low Nocturnal Bladder Capacity

• Status: Completed
• Trial end date: 2005-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Nocturia is defined as waking one or more times to void during the period between going to bed with the intention of sleeping and waking with the intention of arising.The pathophysiology of nocturia is multifactorial and can be complex. Therefore it is important to adopt a systematic approach to identify the possible causal factors of nocturia and to treat them accordingly. Patients with nocturia can be categorized as having one of the following three disorders: (1) nocturnal polyuria (NP) in which the voided urine volume during the hours of sleep exceeds 35% of the 24-hr output, (2) low nocturnal bladder capacity (NBC) causing a nocturnal urinary volume greater than the bladder capacity, (3) or mixed nocturia, a combination of the preceding two categories.

Desmopressin, a synthetic analogue of the antidiuretic hormone (ADH), has been used for many years to treat diabetes insipidus and primary nocturnal enuresis.More recently, it is also known to be effective against nocturia with NP by decreasing night-time urine production.However, it may be associated with an increased risk of developing hyponatremia due to water retention, especially in elderly patients.In the present study, we investigated the safety and efficacy of oral desmopressin for the treatment of mixed nocturia in patients with both NP and a low NBC.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Samsung Medical Center
• Treatments: Deamino Arginine Vasopressin

Criteria

Inclusion Criteria:

• aged ≥18 yr

• nocturia ≥2 voids/night

• nocturnal polyuria index (NPi) >33%

• nocturnal bladder capacity index (NBCi) >1

Exclusion Criteria:

• nocturia due to other defined causes of increased urinary frequency

• primary polydipsia (>40mL/kg/24 h)

• neurogenic bladder dysfunction

• significant bladder outlet obstruction

• urge incontinence

• continued post-voiding residual urine >150mL

• serum sodium levels <135mmol/L

• uncontrolled hypertension characterized by fluid and/or electrolyte imbalance

• use of diuretics

• actual or planned pregnancy