Detemir Energy Expenditure Study

• Status: Unknown status
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

This is a study designed to compare the effects of 2 long-acting insulins, detemir and insulatard, on energy expenditure,weight, fat composition, gut hormone profiles, glycaemic control and fat and muscle gene expression over a 6 month period.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Surrey
• Collaborator: Novo Nordisk A/S
• Treatments: Insulin; Insulin, Isophane; Isophane insulin, beef; Isophane Insulin, Human

Criteria

Inclusion Criteria:

1. Type 2 diabetes

2. Treated with metformin

3. Already on treatment with a long-acting or intermediate insulin.

4. Over 18 years of age,

5. HbA1c > 7.0%

6. BMI 27-40

7. Able and willing to perform self-blood glucose monitoring.

8. Able and willing to maintain consistent eating habits throughout the entire trial period.

9. Able and willing to maintain consistent physical activity level during the entire trial period

Exclusion Criteria:

1. Patients on sulphonylureas or thiazolidinediones

2. Proliferative retinopathy that has required acute treatment within the last six months.

3. Impaired hepatic or renal functions.

4. Cardiac problems.

5. Uncontrolled hypertension (treated or untreated).

6. Mental incapacity, unwillingness or a language barrier precluding adequate understanding or co-operation.