Determination of the ED50 and ED95 of Prophylactic Norepinephrine Infusion for Preventing Post-induction Hypotension in Elderly Patients Undergoing Major Abdominal Surgery

• Status: Recruiting
• Trial end date: 2023-05-30
• Target enrollment: 0
• Participant gender: All

Summary

The goal of this clinical trial is to determine the ED50 and ED95 of prophylactic norepinephrine infusion for preventing post-induction hypotension in elderly patients undergoing major abdominal surgery using up-and-down sequential method . The main question it aims to answer is:

What is the effective concentration of prophylactic norepinephrine infusion for preventing post-induction hypotension in elderly patients.

Participants will receive different concentrations of norepinephrine infusion at the beginning of anesthesia induction until 15 minutes after intubation.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University
• Treatments: Norepinephrine

Criteria

Inclusion Criteria:

• aged 65 to 80 years

• Undergoing major abdominal surgery

• American Society of Anesthesiologists (ASA) physical status of I/II/III

Exclusion Criteria:

• Patient refusal

• Severe untreated or uncontrolled hypertension despite medications

• Bradycardia (heart rate < 50 beat per minute)

• Cardiac morbidities, heart block greater than the first degree

• Severe hepatic and renal dysfunction

• hyperthyroidism

• vascular diseases

• BMI>30

• Monoamine oxidase inhibitors were used 2 weeks before surgery