Determine the Clinical Advantage of IV vs PO Acetaminophen

• Status: Completed
• Trial end date: 2018-12-30
• Target enrollment: 0
• Participant gender: All

Summary

There is limited research on the clinical outcome differences between intravenous (IV) acetaminophen versus oral (PO) acetaminophen. With the costs of intravenous acetaminophen sometimes being almost 100 times the cost of PO acetaminophen, it is not only important fiscally but also clinically to differentiate the benefits of IV vs PO acetaminophen. The proposed research study is to determine the clinical advantages of IV vs PO acetaminophen during the post-operative recovery time for ambulatory surgery patients by analyzing differences in time to first opioid delivery, pain scores, and patient satisfaction.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Yan Lai
• Treatments: Acetaminophen

Criteria

Inclusion Criteria:

• ASA scores I-III

• Ambulatory surgery patients

• Ages 18-75

• Surgeries requiring general anesthesia for hernia surgery

Exclusion Criteria:

• Patients with contraindications to acetaminophen (history of end organ liver dysfunction)

• Known allergy to acetaminophen

• Emergency surgery

• Patients who were not fasted

• Patients who cannot tolerate PO

• Surgery anticipated to last longer than 3 hours or requiring re-dose of acetaminophen

• Pregnancy

• Weight less than 50kg

• Chronic daily narcotic use

• Patients who's anesthetic plan requires regional anesthesia

• Patient refusal to participate or do not have capacity to provide consent.