Development of Clinical Method to Determination Triclosan Retention in Plaque Following Brushing.

• Status: Completed
• Trial end date: 2008-01-01
• Target enrollment: 0
• Participant gender: All

Summary

Clinical research study to determine the anti-plaque efficacy of prototype dentifrices via a 4-day brushing regiment

• Phase: Phase 3
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Colgate Palmolive
• Treatments: Anti-Bacterial Agents; Fluorides; Honokiol; Triclosan

Criteria

Inclusion Criteria:

• Male or female volunteers 18-65 years of age.

• Good general health.

• Must sign informed consent form.

• Must discontinue oral hygiene on the mornings of each appointment and between sampling periods.

• No history of allergy to personal care consumer products, or their ingredients, relevant to any ingredient in the test products as determined by the dental/medical professional monitoring the study.

Exclusion Criteria:

• Medical condition which requires pre-medication prior to dental procedures/visits.

• Medical condition which precludes eating/drinking for 12 hrs.

• History of allergy to common dentifrice ingredients.

• Subjects unable or unwilling to sign the informed consent form.

• Moderate or advanced periodontal disease.

• Two or more decayed untreated dental sites at screening.

• Other disease of the hard or soft oral tissues.

• Impaired salivary function (e.g. Sjogren's syndrome or head and neck irradiation).

• Use of medications that can currently affect salivary flow.

• Current use of antibiotics.

• Use of antibiotics or antimicrobial drugs within 30 days prior to study visit #1.

• Pregnant or nursing women.

• Participation in any other clinical study within 30 days prior to enrollment into this study.

• Use of tobacco products.

• Subjects who must receive dental treatment during the study dates.

• Current use of Antibiotics for any purpose.

• Immune compromised individuals (HIV,AIDS, immuno suppressive drug therapy).