Development of Cognitive Assessment Tools in Parkinson Disease
Status:
Completed
Trial end date:
2011-03-01
Target enrollment:
Participant gender:
Summary
The main objectives of this protocol are as follows:
1. To assess the sensitivity and specificity of ANAM-PD in detecting cognitive status in
patients with Parkinson disease (PD) and healthy controls (HC).
2. To validate the specific individual domains of the ANAM-PD cognitive battery by
comparisons to available standardized cognitive evaluation scales administered to the
patients with Parkinson disease with and healthy control subjects.
3. To evaluate the reliability of the ANAM-PD battery of tests by comparing repeated
administrations of the ANAM-PD battery on a sub-set of subjects with Parkinson disease
and healthy controls.
4. To characterize cholinergic neurotransmission through imaging the vesicular
acetylcholine transporter binding with 123Iodobenzovesamicol (IBVM) and SPECT in PD
patients and healthy controls.
Phase:
Early Phase 1
Details
Lead Sponsor:
Institute for Neurodegenerative Disorders
Collaborators:
United States Department of Defense University of Oklahoma