Development of Pregnenolone as a Treatment for Depression R61
Status:
Recruiting
Trial end date:
2021-10-31
Target enrollment:
Participant gender:
Summary
Pregnenolone, an over-the-counter supplement, is a naturally occurring neurosteroid made in
the adrenal glands and brain. Preclinical research suggests pregnenolone has antidepressant,
cognitive enhancing, and neuroprotective properties, particularly in women. The following
hypothesis will be tested in this trial: pregnenolone is associated with improvement in
depressive symptom severity in women that is associated with changes in the resting state
functional connectivity (rsFC) and GABA.
Phase:
Phase 1
Details
Lead Sponsor:
University of Texas Southwestern Medical Center
Collaborator:
National Center for Complementary and Integrative Health (NCCIH)