Dexamethasone Preoperative for Patients Undergoing Laparoscopy for Suspected Appendicitis

• Status: Completed
• Trial end date: 2015-10-01
• Target enrollment: 0
• Participant gender: All

Summary

For elective abdominal surgery preoperative administration of 8 mg dexamethasone reduces the incidents of postoperative nausea and vomiting (PONV). Whether preoperative administration of 8 mg dexamethasone reduces PONV for patients having acute abdominal surgery has not been established. The investigators wish to see if preoperative administration of 8 mg dexamethasone minimum 30 minutes prior to a diagnostic laparoscopy for suspected appendicitis will reduce the incidents of PONV by 50%. Of secondary interest the investigators want to see if 8 mg dexamethasone preoperative can reduce pain, reduce opioid consumption, postoperative fatigue, duration of time until resumption of work and resumption of normal daily activities, and enhanced the quality of recovery.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Nordsjaellands Hospital
• Collaborator: Zealand University Hospital
• Treatments: BB 1101; Dexamethasone; Dexamethasone 21-phosphate; Dexamethasone acetate

Criteria

Inclusion Criteria:

• Scheduled for a diagnostic laparoscopy for suspected appendicitis

• ASA clas I-III

Exclusion Criteria:

• Known inflammatory bowel disease

• Known autoimmune disease.

• Chronic pain patient.

• Pregnant or breastfeeding.

• In treatment with systemic corticoid steroids or immune-depressants.

• Known glaucoma.

• Known ocular herpes simplex.

• Vaccination within 14 days prior to inclusion.

• Known cushing's disease.

• Known myasthenia gravis.

• Presumably poor compliance with study protocol.