Dexamethasone and Oxygen Support Strategies in ICU Patients With Covid-19 Pneumonia
Status:
Active, not recruiting
Trial end date:
2021-12-31
Target enrollment:
Participant gender:
Summary
The main manifestation of COVID-19 is acute hypoxemic respiratory failure (AHRF). In patients
with AHRF, the need for invasive mechanical ventilation is associated with high mortality.
Two hypotheses will be tested in this study. The first hypothesis is the benefit of
corticosteroid therapy on severe COVID-19 infection admitted in ICU in terms of survival.
The second hypothesis is that, in the subset of patients free of mechanical ventilation at
admission, either Continuous Positive Airway Pressure (CPAP) or High-Flow Nasal Oxygen (HFNO)
allows to reduce intubation rate safely during COVID-19 related acute hypoxemic respiratory
failure.