Dexamethasone and Post-tonsillectomy Pain in Children
Status:
Completed
Trial end date:
2019-06-27
Target enrollment:
Participant gender:
Summary
The investigators will use a prospective randomized, controlled design utilizing a single
preoperative dose of oral dexamethasone or placebo to achieve these specific aims:
- Specific Aim 1: To evaluate the potential for a single preoperative dose of oral
dexamethasone administered the night before surgery to reduce the incidence and severity
of early post tonsillectomy pain (PTP) in children
- Specific Aim 2: To prospectively evaluate differences in early PTP experience between
overweight/obese children and their lean peers.
- Specific Aim 3: To determine whether circulating inflammatory markers are strongly
linked to PTP severity in children and whether they could be potential contributors to
the higher pain experienced by overweight/obese children following Tonsillectomy and or
Adenoidectomy.
Phase:
Phase 4
Details
Lead Sponsor:
Nationwide Children's Hospital University of Michigan
Collaborator:
National Institute of General Medical Sciences (NIGMS)