Dexamethasone and Postoperative Bleeding Following Tonsillectomy in Children
Status:
Recruiting
Trial end date:
2023-10-01
Target enrollment:
Participant gender:
Summary
Tonsillectomy is one of the most frequently performed surgical interventions in children.
However, it is associated with a high incidence of PostOperative Nausea and Vomiting (PONV),
severe pain and haemorrhage.
There is strong evidence on the efficacy of Dexamethasone in reducing the incidence of PONV
and pain after tonsillectomy, which led to consider this drug as a first line treatment in
routine anaesthesia practice in such surgical setting. However, in the last decade, there
have been arguments about the potential role of Dexamethasone in increasing the risk of
postoperative bleeding in children and studies addressing the haemorrhage risk following
administration of Dexamethasone for tonsillectomy are inconclusive.Thus, this study is aimed
at providing evidence for the safety profile of Dexamethasone with regard to the risk of
post-tonsillectomy bleeding in children when administered as a single intraoperative dose.